| Autor: |
Yu, V. K., Praliev, K. D., Fomicheva, E. E., Mukhasheva, R. D., Klepikova, S. G. |
| Předmět: |
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| Zdroj: |
Chemistry of Heterocyclic Compounds; Apr2006, Vol. 42 Issue 4, p512-519, 8p, 1 Diagram, 3 Charts |
| Abstrakt: |
New 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones were synthesized by the double Mannich cyclization of tetrahydrothiopyran-4-one with suitable alkoxyalkylamines and paraformaldehyde in acetous methanol. Wolff-Kishner decarbonylation of these bicyclic ketones gave 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonanes. The reduction of 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones by alkali metal hydride complexes leads to a mixture of two stereoisomeric secondary alcohols, which are epimers at C(9). Active analgesic, antiarrhythmic, and antibacterial compounds were found among these products. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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