Conversion of Major Ginsenoside Rb1 to Ginsenoside F2 by Caulobacter leidyia.

Autor: Le-Qin Cheng, Myung Kyun Kim, Jun-Won Lee, Youn-Jin Lee, Deok-Chun Yang
Předmět:
Zdroj: Biotechnology Letters; Jul2006, Vol. 28 Issue 14, p1121-1127, 7p
Abstrakt: Ginsenoside Rb1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong β-glucosidase-producing activity, converted ginsenoside Rb1 to the active metabolites by 91%. The structures of the resultant metabolites were identified by NMR. Ginsenoside Rb1 had been consecutively converted to ginsenoside Rd (1), F2 (2) and compound K (3) via the hydrolyses of 20-C β-(1→6)-glucoside, 3-C β-(1→2)-glucoside, and 3-C β-glucose of ginsenoside Rb1. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index