Immunoglobulin VH Genes and CD38 Expression Analysis in B-Cell Chronic Lymphocytic Leukemia.

Autor: Bagli, Laura, Zucchini, Alessandra, Innoceta, Anna Maria, Zaccaria, Alfonso, Cipriani, Raffaella, Fattori, Pier Paolo, Ravaioli, Alberto
Předmět:
Zdroj: Acta Haematologica; 2006, Vol. 116 Issue 1, p72-74, 3p, 1 Chart, 1 Graph
Abstrakt: Examines the correlation of immunoglobulin heavy chain gene mutation analysis and CD38 expression on B cells in line with the clinical diagnosis of B-cell chronic lymphocytic leukemia (B-CLL). Disadvantages of immunoglobulin heavy chain gene mutation analysis as a diagnostic tool for B-CLL; Controversy regarding the usefulness of the CD38 expression levels as a B-CLL marker; Analysis of heavy mutation status and CD38 expression in several B-CLL patients.
Databáze: Complementary Index