| Autor: |
Akif Öztürk, Mehmet, Oktar, Suna O., Ünverdi, Selman, Üreten, Kemal, Göker, Berna, Haznedaroglu, Seminur, Sungur, Gülten, Reis, Kadriye A., Mesut Onat, A. |
| Předmět: |
|
| Zdroj: |
Rheumatology International; Aug2006, Vol. 26 Issue 10, p867-872, 6p, 3 Charts, 1 Graph |
| Abstrakt: |
Subclinical atherosclerosis can be demonstrated by measuring the intima-media thickness (IMT) of the carotid arteries by high-resolution B-mode ultrasonography (US). Endothelial injury appears a key event in the atherogenesis. Endothelial cell activation and/or injury are the characteristic features of Behçet’s disease (BD). In this study, we investigated morphologic evidence of subclinical atherosclerosis in the BD patients by using high-resolution B-mode US. Thirty-four patients with BD without arterial involvement (male/female 21/13; mean age 34.6±8.5 years) were individually matched to control subjects on the basis of age (within 2 years) and sex. Subjects with diabetes mellitus, hypertension, evidence of myocardial infarction or cerebrovascular disease, and patients on long-term steroids (i.e., >6 months) were excluded from the study. Mean IMT values of the right carotid arteries were 0.81±0.17 mm for patients with BD, and 0.54±0.13 mm for healthy controls ( P<0.001). Mean IMT values of the left carotid arteries were 0.82±0.16 mm for patients with BD, and 0.55±0.12 mm for healthy controls ( P<0.001). The overall prevalence of carotid atherosclerotic plaques was higher among the patients than the controls [prevalence of plaques were 17.6% (6/34) in BD patients and 0% in healthy controls, P<0.05]. In conclusion, our data indicate morphologic evidence of subclinical atherosclerosis in patients with BD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink