Association of Cigarette Smoking With HIV Prognosis Among Women in the HAART Era: A Report From the Women's Interagency HIV Study.

Autor: Feldman, Joseph G., Minkoff, Howard, Schneider, Michael F., Gange, Stephen J., Cohen, Mardge, Watts, D. Heather, Gandhi, Monica, Mocharnuk, Robert S., Anastos, Kathryn
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Zdroj: American Journal of Public Health; Jun2006, Vol. 96 Issue 6, p1060-1065, 6p
Abstrakt: Objective. We assessed the association of cigarette smoking with the effectiveness of highly active antiretroviral therapy (HAART) among low-income women. Methods. Data were analyzed from the Women's Interagency HIV Study, a multisite longitudinal study up to 7.9 years for 924 women representing 72% of all women who initiated HAART between July 1, 1995, and September 30, 2003, Results. When Cox's regression was used after control for age, race, hepatitis C infection, illicit drug use, previous antiretroviral therapy, and previous AIDS, smokers on HAART had poorer viral responses (hazard ratio [HR] = 0.79; 95% confidence interval [CI] = 0.67,0.93) and poorer immunologic response (HR=0,85; 95% CI = 0.73, 0.99). A greater risk of virologic rebound {HR= 1.39; 95% Cl = 1.06,1.69) and more frequent immunologic failure (HR = 1.52; 95% 01 = 1.18,1.96) were also observed among smokers. There was a higher risk of death (HR = 1.53; 95% CI = 1.08, 2.19) and a higher risk of developing AIDS (HR = 1.36; 95% Cl = 1,07,1.72) but no significant difference between smokers and nonsmokers in the risk of death due to AIDS, Conclusions. Some of the benefits provided by HAART are negated in cigarette smokers. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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