| Autor: |
Hurria, Arti, Rosen, Carol, Hudis, Clifford, Zuckerman, Enid, Panageas, Katherine S., Lachs, Mark S., Witmer, Matthew, van Gorp, Wilfred G., Fornier, Monica, D'Andrea, Gabriella, Moasser, Mark, Chau Dang, van Poznak, Catherine, Hurria, Anju, Holland, Jimmie |
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| Zdroj: |
Journal of the American Geriatrics Society; Jun2006, Vol. 54 Issue 6, p925-931, 7p, 3 Charts |
| Abstrakt: |
OBJECTIVES: To report on the longitudinal cognitive functioning of older women receiving adjuvant chemotherapy for breast cancer. DESIGN: Neuropsychological and functional status testing were performed before chemotherapy and 6 months after chemotherapy. SETTING: Cancer center. PARTICIPANTS: Thirty-one patients aged 65 and older with Stage I to III breast cancer. Of the 31 patients enrolled, three refused posttesting, and 28 were evaluable. MEASUREMENTS: The following domains of cognitive function were examined: attention; verbal memory; visual memory; and verbal, spatial, psychomotor, and executive functions. RESULTS: Participants had a mean age of 71 (range 65–84): 39% Stage I, 50% Stage II, and 11% Stage III. The number of scores 2 standard deviations (SDs) below the norm were calculated for each patient before and 6 months after chemotherapy; 14 (50%) had no change, 11 (39%) worsened, and three (11%) improved ( P=.05). Seven patients (25%) experienced a decline in cognitive function, defined as a 1-SD decline from pre- to posttesting in two or more neuropsychological domains. Exploratory analyses revealed no significant difference between functional status, comorbidity, and depression scale scores and change in overall quality-of-life scores before and after chemotherapy. CONCLUSION: In this cohort of older women receiving adjuvant chemotherapy, a subset experienced a decline in cognitive function from before chemotherapy to 6 months after chemotherapy. Further prospective study is needed to confirm these observations and to identify the subgroup at special risk. [ABSTRACT FROM AUTHOR] |
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