| Autor: |
Breivik, Torbjørn, Gundersen, Yngvar, Myhrer, Trond, Fonnum, Frode, Osmundsen, Harald, Murison, Robert, Gjermo, Per, von Hörsten, Stephan, Opstad, Per Kristian |
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| Zdroj: |
Journal of Clinical Periodontology; Jul2006, Vol. 33 Issue 7, p469-477, 9p, 4 Graphs |
| Abstrakt: |
Objective: To test the hypothesis that the olfactory bulbectomy model of depression in rats could influence susceptibility to ligature-induced periodontitis, and that chronic treatment with the anti-depressant drug tianeptine could attenuate this effect. Material and Methods: Tianeptine was given twice daily (10 mg/kg, i.p.) during the entire experiment, starting 29 days before induction of olfactory bulbectomy and periodontitis. Olfactory bulbectomized (OB) rats and sham-operated rats were given saline in a similar manner. Periodontal disease was assessed when the ligatures had been in place for 21 days. Two hours before decapitation, rats were injected with lipopolysaccharide (LPS;100 μg/kg, i.p.) to induce a robust immune and stress response. Results: Compared with sham-operated controls, OB rats developed significantly more periodontal bone loss, exhibited characteristic behavioural responses in a novel open field test, and showed a decreased expression of glucocorticoid receptors (GRs) in the hippocampus. LPS provoked a significantly larger increase in circulating levels of the stress hormone corticosterone and the cytokine transformation growth factor (TGF)-1β but smaller tumour necrosis factor (TNF)-α levels. Tianeptine treatment of OB rats significantly inhibited peridodontal bone loss, normalized behavioural responses, enhanced TGF-1β levels, and abolished TNF-α decrease, but did not attenuate the increased corticosterone response and the decreased hippocampal GR expression. Conclusions: These experimental results are consistent with an emerging literature showing that life stress, anxiety, depression, pathological grief, and poor coping behaviour may dysregulate regulatory mechanisms within the brain involved in immune regulation, and thereby alter immune responses and influence the susceptibility/resistance to inflammatory disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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