| Autor: |
Weingart, C., Leingärtner, T., Bergler, T., Krüger, B., Mack, M., Banas, B., Krämer, B. K. |
| Předmět: |
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| Zdroj: |
Kidney & Blood Pressure Research; 2004, Vol. 27 Issue 5/6, p341-341, 1/3p |
| Abstrakt: |
Objective: Acute effects of drug administration on renal arterial resistance index are still discussed controversial. In our study we investigated the immediate effects of cyclosporin A (CyA) and tacrolimus (FK 506) on renal arterial resistance indices in patients with stable allograft function after renal allotransplantation. Additionally we studied the effects of nitroglycerine spray on resistance indices. Methods: Resistance indices were measured by color Doppler sonography at baseline, 1 hour after and 2 hours after calcineurin inhibitor intake and another 30 minutes after nitroglycerine spray had been administered after the 2 hours measurement. 34 renal transplant recipients were examined. 16 patients received CyA, 18 patients received FK506. Whole blood levels of calcineurin inhibitors were taken at each time point. Arterial blood pressure Results: Mean RI rose significantly in both groups after one hour and was still significantly elevated after two hours. There was no significant rise of mean arterial blood pressure nor was there any correlation between whole blood levels of calcineurin inhibitors and mean RI. 30 minutes after administration of nitroglycerine spray, mean RI decreased significantly to a level even below baseline. Mean arterial blood pressure also decreased after administration of nitroglycerine. Conclusions: Renal arterial resistance index markedly depends on immediate effects of drug intake, especially calcineurin inhibitors and vasoactive substances like nitrates which makes it necessary to keep standardized conditions when using resistance indices as a tool in follow-up after renal transplantation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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