| Autor: |
Koryakin, S., Ul’yanenko, S., Savina, E., Baranov, A., Krivosheev, Ya., Yadrovskaya, V. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Dec2005, Vol. 39 Issue 12, p627-629, 3p, 1 Chart, 3 Graphs |
| Abstrakt: |
The influence of local IR irradiation of the experimental melanoma B-16 zone on the distribution of sodium mercaptododecaborate labeled with radioactive iodine (131I-BSH) in mice was studied for two regimes of thermal treatment (before and after administration of the labeled compound). It was established that a considerable increase in the 131I-BSH content in the model tumor was reached in the case of IR irradiation performed 1 h after drug administration. Based on these data, IR radiation can be considered an effective modifier of 131I-BSH uptake in tumors, increasing the efficacy of boron-enhanced neutron capture therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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