Cell density and contraction regulate p38 MAP kinase-dependent responses in neonatal rat cardiac...

Autor: Hines, Wirt A., Thoburn, Jacqueline
Předmět:
Zdroj: American Journal of Physiology: Heart & Circulatory Physiology; Jul99, Vol. 277 Issue 1, pH331, 11p, 3 Black and White Photographs, 6 Graphs
Abstrakt: Examines the role of p38 during induction of the atrial natriuretic factor (ANF) promoter and morphological hypertrophy in response to phenylephrine. Involvement of mitogen-activated protein kinase p38 in the induction of ANF promoter in cardiac myocytes; How increasing contraction rate by rapid electrical pacing induces ANF gene expression that requires p38 activity; How rapid electrical pacing induces phosphorylation and activation of p38.
Databáze: Complementary Index