| Autor: |
Gudkov, S. V., Shtarkman, I. N., Smirnova, V. S., Chernikov, A. V., Bruskov, V. I. |
| Předmět: |
|
| Zdroj: |
Doklady Biochemistry & Biophysics; Mar2006, Vol. 407 Issue 1, p47-50, 4p, 4 Graphs |
| Abstrakt: |
The article demonstrates that purine nucleotides are natural antioxidants and protect DNA from damage by reactive oxygen species (ROS) generated by ionizing radiation and heat. The nucleotides decrease heat-induced generation in aqueous solutions of ROS. It was found that guanosine and inosine function as radioprotectors which increase the survival rate of mice exposed to γ-radiation and that they are effective when injected after irradiation. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
