| Autor: |
Courtin, David, Jamonneau, Vincent, Mathieu, Jean-François, Koffi, Mathurin, Milet, Jacqueline, Yeminanga, Claude Sese, Kumeso, Victor Kande Betu, Cuny, Gérard, Bilengue, Constantin Miaka Mia, Garcia, Andr |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; May2006, Vol. 11 Issue 5, p647-653, 7p |
| Abstrakt: |
Background Immunological studies suggest that human African trypanosomiasis (HAT) is associated with inflammatory responses. A better understanding of the complex cytokine interactions regulating HAT infections is essential to elucidate the mechanisms of generalized immunosuppression. Method We determined levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)- α and interferon (IFN)- γ protein levels in plasma samples from three groups of individuals from the Democratic Republic of Congo: (i) HAT cases; (ii) seropositive individuals for whom parasite detection was negative and (ii) controls. Results Plasma levels of six cytokines were significantly higher in HAT cases than in both controls ( P < 0.003) and seropositive individuals ( P < 0.016). IL-2 and IL-10 concentrations were significantly lower ( P < 0.02) in the seropositive group than in the control one. Conclusion Human African trypanosomiasis leads to the development of strong cytokine responses, indicating the potential involvement of IL-2 and IL-10 in the phenomenon of seropositivity without parasitological confirmation. This strongly suggests the involvement of immunity in this particular aspect of HAT epidemiology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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