| Autor: |
Nagarajan, Srinivasan R., Meyer, Jane M., Miyashiro, Julie M., Engleman, V. Wayne, Freeman, Sandra K., Griggs, David W., Klover, Jon A., Nickols, G. Alan |
| Předmět: |
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| Zdroj: |
Chemical Biology & Drug Design; Feb2006, Vol. 67 Issue 2, p177-181, 5p |
| Abstrakt: |
A peptidomimetic inhibitor of the integrin αv β3 has been substantially modified to produce several new nonpeptidic antagonists. These inhibitors are simpler to synthesize and belong to new classes of scaffolds. Some of the compounds served as the initial lead for further optimization, which led to the discovery of potent and selective inhibitors of the integrin αv β3. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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