| Autor: |
Richard Lytle, Zhihong Jiang, Xiao Zheng, Keith Rich |
| Zdroj: |
Journal of Neuro-Oncology; Jul2004, Vol. 68 Issue 3, p233-241, 9p |
| Abstrakt: |
Oligodendroglial differentiation in gliomas is associated with enhanced sensitivity to chemotherapy. Anti-apoptotic proteins, Bcl-xL and Bcl-2, are over-expressed in early passage cell lines derived from glioblastomas. Down-regulation of Bcl-xL and Bcl-2 with DNA antisense oligonucleotides promotes cell death in glioblastoma cells. Changes of expression of Bcl-xL and Bcl-2 after chemotherapy treatment have not been studied in glioma subtypes. The current experiments correlate decreased expression of both Bcl-xL and Bcl-2 after BCNU chemotherapy and cell death in two oligodendroglioma-derived cell lines. Expression of Bcl-2 family member proteins Bcl-xL, Bcl-2, and Bax were assessed in glioma cells both before and after chemotherapy treatment. Cell survival was assessed with a crystal violet bioassay. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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