| Autor: |
Sakamoto, F. H., Colleoni, G. W. B, Teixeira, S. P., Yamamoto, M., Michalany, N. S., Almeida, F. A., Chiba, A. K., Petri, V., Fernandes, M. A., Pombo-de-Oliveira, M. S. |
| Předmět: |
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| Zdroj: |
International Journal of Dermatology; Apr2006, Vol. 45 Issue 4, p447-449, 3p, 3 Color Photographs |
| Abstrakt: |
Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes, 1 and is caused by human T-lymphotropic virus type I (HTLV-I); 2 an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa. 3,4 Seroepidemiological studies suggest that it is also endemic in Brazil. 5 Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells. 6,7 Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases 8 with unknown etiology. 9 The two most common presentations of CTCL are mycosis fungoides (MF) and Sézary syndrome (SS). 10–13 However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches. 14 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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