| Autor: |
Kadieva, M., Oganesyan, É., Mutsueva, S. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Oct2005, Vol. 39 Issue 10, p520-532, 13p, 37 Diagrams |
| Abstrakt: |
Five subtypes (D1 — D5) of dopamine receptors have been cloned and characterized so far, but the contribution of each particular receptor to the development of Parkinson’s disease (PD) has not been completely determined because of the absence of the corresponding selective ligands. However, it has been suggested that the main role in the PD development is played by the D2-type receptors. For this reason, the review focuses predominantly on the use of D2-agonists as antiparkinsonian agents. The main issues of QSAR for these substances are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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