| Autor: |
Batia Kaplan, Brian Martin, Olga Boykov, Rivka Gal, Mordechai Pras, Itzhak Shechtman, Milton Saute, Mordechai Kramer |
| Zdroj: |
Virchows Archiv: European Journal of Pathology; Oct2005, Vol. 447 Issue 4, p756-761, 6p |
| Abstrakt: |
Localized pulmonary amyloidosis is a rare condition whose pathogenesis is insufficiently understood. In the present study, we report a case of localized pulmonary amyloidosis associated with lung-restricted lymphoplasmacytoid lymphoma, monoclonal for immunoglobulin (Ig) G lambda (λ). Biochemical microtechniques have been applied for extraction, purification, and characterization of amyloid proteins. Surprisingly, chemical analysis of these proteins revealed a not-previously-described case of combined deposits containing Ig fragments of gamma heavy chain (variable domain) and λ light chain (constant domain). In view of the absence of circulating monoclonal Ig, this case supports the hypothesis that localized amyloid is formed by local plasmacytoid cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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