Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients.

Autor: Christine Fumeron, Thao Nguyen-Khoa, Claudine Saltiel, Messeret Kebede, Claude Buisson, Tilman B. Drüeke, Bernard Lacour, Ziad A. Massy
Zdroj: Nephrology Dialysis Transplantation; Sep2005, Vol. 20 Issue 9, p1874-1879, 6p
Abstrakt: Background. There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients.Methods. We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 mg three times per week) for 2 months on well-defined oxidative and inflammatory markers in 33 chronic haemodialysis (HD) patients.Results. Normalization of plasma total vitamin C and ascorbate levels by oral vitamin C supplementation did not modify plasma levels of carbonyls, C-reactive protein and albumin, or erythrocyte concentrations of reduced and oxidized glutathione.Conclusion. Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index