| Autor: |
Takahashi, Noritoshi, Kitazawa, Haruki, Shimosato, Takeshi, Iwabuchi, Noriyuki, Jin-zhong Xiao, Iwatsuki, Keiji, Kokubo, Sadayuki, Saito, Tadao |
| Předmět: |
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| Zdroj: |
FEMS Immunology & Medical Microbiology; Apr2006, Vol. 46 Issue 3, p461-469, 9p, 1 Chart, 9 Graphs |
| Abstrakt: |
The immunostimulatory oligodeoxynucleotide (ODN) BL07 (5′-GCGTCGGTTTCGGTGCTCAC-3′) was identified from the genomic DNA of the probiotic strain Bifidobacterium longum BB536. ODN BL07 stimulated B-lymphocyte proliferation and induced interleukin-12 (IL-12) production in macrophage-like J774.1 cells. ODNs BL07 and BL07S (modified with phosphorothioate backbone) significantly inhibited immunoglobulin E (IgE) production and stimulated interferon-γ (IFN-γ) and IL-12 production, but did not affect IL-4 secretion in murine splenic cells of ovalbumin-primed BALB/c mice. These ODNs also significantly inhibited production of IgE in purified murine B cells in the presence of IL-4 and anti-CD40. The results suggest the potential of ODNs BL07 and BL07S in preventing IgE-related immune responses and the possible involvement of ODN BL07 in the antiallergic efficacy of B. longum BB536. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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