| Autor: |
Cardona, Kenneth, Korbutt, Gregory S., Milas, Zvonimir, Lyon, James, Cano, Jose, Wanhong Jiang, Bello-Laborn, Hameeda, Hacquoil, Brad, Strobert, Elizabeth, Gangappa, Shivaprakash, Weber, Collin J., Pearson, Thomas C., Rajotte, Ray V., Larsen, Christian P. |
| Předmět: |
|
| Zdroj: |
Nature Medicine; Mar2006, Vol. 12 Issue 3, p304-306, 3p, 2 Graphs |
| Abstrakt: |
We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
