Antiviral Activity of Some 2'-Deoxyuridine 5-Arylethynyl Derivatives.

Autor: V. L. Andronova, M. V. Skorobogatyi, E. V. Manasova, Yu. A. Berlin, V. A. Korshun, G. A. Galegov
Zdroj: Russian Journal of Bioorganic Chemistry; May2003, Vol. 29 Issue 3, p262-266, 5p
Abstrakt: 5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by crosslinking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index