| Autor: |
Van Heeswijk, Rolf P. G., Cooper, Curtis L., Foster, Brian C., Chauhan, Bobby M., Shirazi, Farshad, Seguin, Isabelle, Phillips, Elizabeth J., Mills, Ed |
| Předmět: |
|
| Zdroj: |
Pharmacotherapy; Dec2005, Vol. 25 Issue 12, p1725-1728, 4p, 1 Chart, 1 Graph |
| Abstrakt: |
Study Objectives. To investigate the effect of high-dose vitamin C on cytochrome P450 (CYP) 3A4 activity, and to evaluate possible sex-specific effects on CYP3A4 activity Design. Single-center longitudinal study. Setting. Tertiary- and specialty-care teaching hospital. Subjects. Fourteen healthy Caucasian adult volunteers (seven men, seven women). Intervention. Subjects self-administered vitamin C 500 mg twice/day for 14 days. Measurements and Main Results. Hepatic CYP3A4 activity was measured by using the erythromycin breath test on days 1 (baseline) and 15. Overall, no significant effect of vitamin C on CYP3A4 activity was observed. Sex and baseline results were significant predictors of changes in CYP3A4 activity. In men, mean activity increased by 21.9% (95% confidence interval -3.88-47.6%). The effect in women was not consistent. Conclusion. Sex and baseline CYP3A4 activity appeared to influence the effect of vitamin C on CYP3A4 activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text