An experimental solution for the Luria-Delbruck fluctuation problem in measuring hypermutation rates.

Autor: Bachl, Jurgen, Dessing, Mark
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 06/08/99, Vol. 96 Issue 12, p6847, 3p, 1 Diagram, 1 Chart, 1 Graph
Abstrakt: Presents information on a study that transfected a cell line harboring all trans-acting elements necessary for hypermutation with a plasmid harboring the major cis-acting elements plus a green flourescent protein gene containing a premature chain-termination codon. Relationship of the codon and transfected cells; Role of revertants to the frequency of mutants; Information on the Luria and Delbruck fluctuation effect.
Databáze: Complementary Index