Lack of Association Between Androgen Receptor Polymorphisms and Bone Mineral Density or Physical Function in Older Men.

Autor:	Kenny, A. M., McGee, D., Joseph, C., Covault, J., Abreu, C., Raisz, L. G.
Předmět:	ANDROGENS ANDROSTANE BONE density OLDER men FEMUR neck BONES
Zdroj:	Endocrine Research; Nov2005, Vol. 31 Issue 4, p285-293, 9p, 2 Charts, 2 Graphs
Abstrakt:	Individuals whose androgen receptors have short polyglutamine tracts (resulting from CAG repeats) may have greater receptor signaling activity of the androgen receptor. We evaluated the association between bone mineral density (BMD) and CAG repeats in 91 older men with normal (control) and low femoral neck (FN) BMD (OP) or a history of femoral fracture (FX). Bioavailable testosterone (BioT) and physical performance, including composite score (EPESE) and physical activity (PASE), were also measured. Comparing FX, OP, and control subjects, we observed BMD T scores of 22.16 6 1.08, 22.26 6 0.74, and 20.20 6 0.40 (p [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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