| Autor: |
Berger, T. G., Kiesewetter, F., Maczek, C., Bauer, N., Lueftl, M., Schuler, G., Simon, M. |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; Feb2006, Vol. 20 Issue 2, p178-183, 6p |
| Abstrakt: |
Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-α) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-α and interferon-γ (IFN-γ), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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