| Autor: |
Graves, Jonathan E, Bates, James N, Kooy, Neil W, Lewis, Stephen J |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Pharmacology & Physiology; Dec2005, Vol. 32 Issue 12, p1137-1141, 5p, 1 Graph |
| Abstrakt: |
1. The aim of the present study was to assess the effects of the potent oxidant and nitrating agent peroxynitrite on the haemodynamic actions of the endothelium-derived S-nitrosothioll- S-nitrosocysteine. 2. The haemodynamic actions ofl- S-nitrosocysteine (12.5–100 nmol/kg, i.v.) were determined in pentobarbital-anaesthetized rats before and after the induction of tachyphylaxis to peroxynitrite achieved by giving 10 intravenous injections of a 10 µmol/kg dose. 3. l- S-Nitrosocysteine elicited dose-dependent reductions in mean arterial blood pressure and in hindquarter and mesenteric vascular resistance. 4. Thel- S-nitrosocysteine-induced responses were substantially attenuated after administration of peroxynitrite. 5. We have reported previously that nitric oxide-mediated vasodilation is not diminished after the induction of tachyphylaxis to peroxynitrite. Taken together, these findings support the concept that peroxynitrite reduces the vasodilator actions ofl- S-nitrosocysteine via oxidation and/or nitration of putative membrane-bound S-nitrosothiol recognition sites. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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