| Autor: |
Bremner, Alan, Roked, Sohere, Robinson, Rebecca, Phillips, Ian, Beattie, Mark |
| Předmět: |
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| Zdroj: |
Acta Paediatrica; Dec2005, Vol. 94 Issue 12, p1855-1858, 4p, 1 Graph |
| Abstrakt: |
Aims: Faecal calprotectin, a neutrophil cytosolic protein, is raised in inflammatory bowel disease. We assessed this investigation in evaluating children with chronic intestinal symptoms.Methods: Stool samples from 100 children aged 5-17 years (referrals to the regional paediatric gastroenterology service) were tested using a commercially available kit.Results: Calprotectin was higher in inflammatory bowel disease than normal children (p<0.0001) or in those with functional constipation (p<0.0001). The overall specificity for organic bowel disorders was 85%. Calprotectin correlated with C-reactive protein in inflammatory bowel disease (p=0.001), and clinical disease activity in ulcerative colitis (p=0.017), but not with disease activity in Crohn's disease.Conclusion: Raised faecal calprotectin should prompt further assessment in children with chronic intestinal symptoms, since an organic bowel disorder is likely. However, calprotectin cannot be regarded as a specific test for idiopathic inflammatory bowel disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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