| Autor: |
DiRocco, Joseph D., Pavone, Lucio A., Carney, David E., Lutz, Charles J., Gatto, Louis A., Landas, Steve K., Nieman, Gary F. |
| Předmět: |
|
| Zdroj: |
Intensive Care Medicine; Jan2006, Vol. 32 Issue 1, p140-148, 9p, 1 Color Photograph, 3 Diagrams, 2 Charts, 4 Graphs |
| Abstrakt: |
Objective: To determine whether pathological alterations in alveolar mechanics (i.e., the dynamic change in alveolar size and shape with ventilation) at a similar level of lung injury vary depending on the cause of injury.Design and Setting: Prospective controlled animal study in a university laboratory.Subjects: 30 male Sprague-Dawley rats (300-550 g).Interventions: Rats were separated into one of four lung injury models or control (n=6): (a) 2% Tween-20 (Tween, n=6), (b) oleic acid (OA, n=6), (c) ventilator-induced lung injury (VILI, PIP 40/ZEEP, n=6), (d) endotoxin (LPS, n=6). Alveolar mechanics were assessed at baseline and after injury (PaO2/FIO2 <300 mmHg) by in vivo microscopy.Measurements: Alveolar instability (proportional change in alveolar size during ventilation) was used as a measurement of alveolar mechanics.Results: Alveoli were unstable in Tween, OA, and VILI as hypoxemia developed (baseline vs. injury: Tween, 7+/-2% vs. 67+/-5%; OA: 3+/-2% vs. 82+/-9%; VILI, 4+/-2% vs. 72+/-5%). Hypoxemia after LPS was not associated with significant alveolar instability (baseline vs. injury: LPS, 3+/-2 vs. 8+/-5%).Conclusions: These data demonstrate that multiple pathological changes occur in dynamic alveolar mechanics. The nature of these changes depends upon the mechanism of lung injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink