SYNTHESES OF ADDUCTS OF ACTIVE METABOLITES OF CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS WITH 2′-DEOXYRIBONUCLEOSIDES.

Autor:	Harvey, RonaldG., Dai, Qing, Ran, Chongzhao, Lim, Keunpoong, Blair, Ian, Penning, TrevorM.
Předmět:	ORGANIC synthesis BIOSYNTHESIS BIOMOLECULES METABOLITES HYDROCARBONS ORGANIC compounds ANTHRACENE NITROGEN CHEMICAL ecology
Zdroj:	Polycyclic Aromatic Compounds; Nov/Dec2005, Vol. 25 Issue 5, p371-391, 21p, 22 Diagrams
Abstrakt:	Syntheses are reported for: (1) adducts of the quinone metabolites of benzo[a]pyrene (BPQ) and benz[a]anthracene (BAQ) with 2′-deoxyadenosine and 2′-deoxyguanosine; (2) 15 N-labelled analogs of these adducts (four or five nitrogen atoms 15 N-labelled); (3) depurinated adducts of BPQ and BAQ with adenine or guanine covalently linked to the N7 or N9 positions of the purine bases; (4) 13 C-labelled derivatives of benzo[a]pyrene, BPQ, benzo[a]pyrene trans-7,8-dihydrodiol, and the benzo[a]pyrene anti-diol epoxide (with 13 C-atoms at the 5- and 11-positions); and (5) depurinated adducts formed by reactions of the benzo[a]pyrene radical-cation at the C 8 -, N 7 -, and N 9 -positions of adenine and guanine. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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