Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression.

Autor: Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Brumbach, B. H., Watchman, M., Gelenberg, A. J.
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Zdroj: Acta Psychiatrica Scandinavica; Jan2006, Vol. 113 Issue 1, p31-35, 5p, 1 Chart
Abstrakt: Objective: Postpartum depression (PPD) affects 10–15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD. Method: The efficacy of omega-3 fatty acids for PPD was assessed in an 8-week dose-ranging trial. Subjects were randomized to 0.5 g/day ( n = 6), 1.4 g/day ( n = 3), or 2.8 g/day ( n = 7). Results: Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post-treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre- or post-test scores, or change in scores. The treatment was well tolerated. Conclusion: This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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