Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome.

Autor:	Lee, J.‐S., Yoo, S.‐S., Cho, S.‐Y., Ock, S.‐M., Lim, M.‐K., Panych, L. P.
Předmět:	TOURETTE syndrome DISEASES THALAMUS THALAMUS diseases MAGNETIC resonance imaging DIAGNOSTIC imaging PATHOLOGICAL physiology
Zdroj:	Acta Psychiatrica Scandinavica; Jan2006, Vol. 113 Issue 1, p64-67, 4p, 1 Chart
Abstrakt:	Objective: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). Method: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. Results: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. Conclusion: Our findings provide new evidence of abnormal thalamic volume in pediatric TS. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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