| Autor: |
Kim, D. J., Bility, M. T., Billin, A. N., Willson, T. M., Gonzalez, F. J., Peters, J. M., Cidlowski, J. A. |
| Předmět: |
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| Zdroj: |
Cell Death & Differentiation; Jan2006, Vol. 13 Issue 1, p53-60, 8p, 1 Diagram, 3 Graphs |
| Abstrakt: |
Peroxisome proliferator-activated receptor (PPAR) β-null mice exhibit exacerbated epithelial cell proliferation and enhanced sensitivity to skin carcinogenesis, suggesting that ligand activation of PPARβ will inhibit keratinocyte proliferation. By using of a highly specific ligand (GW0742) and the PPARβ-null mouse model, activation of PPARβ was found to selectively induce keratinocyte terminal differentiation and inhibit keratinocyte proliferation. Additionally, GW0742 was found to be anti-inflammatory due to inhibition of myeloperoxidase activity, independent of PPARβ. These data suggest that ligand activation of PPARβ could be a novel approach to selectively induce differentiation and inhibit cell proliferation, thus representing a new molecular target for the treatment of skin disorders resulting from altered cell proliferation such as psoriasis and cancer.Cell Death and Differentiation (2006) 13, 53–60. doi:10.1038/sj.cdd.4401713; published online 15 July 2005 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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