| Autor: |
Béthencourt, Mathilde I., Barriet, David, Frangi, Nathalie M., Lee, T. Randall |
| Předmět: |
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| Zdroj: |
Journal of Adhesion; Oct2005, Vol. 81 Issue 10/11, p1031-1048, 18p, 1 Diagram, 4 Charts, 2 Graphs |
| Abstrakt: |
This manuscript introduces a new family of cyclic acetal-terminated alkanethiols used to prepare self-assembled monolayers (SAMs) on gold. The new SAMs, which are designed as variants of the biocompatible protein-repellant surfaces generated from thin films of oligoethylene glycol (OEG) or polyethylene glycol (PEG), were characterized by ellipsometry, contact-angle goniometry, and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS). A preliminary study of protein adhesion was also performed using fibrinogen as a model protein. The interfacial structure and properties of the new SAMs were compared with those generated from OEG-terminated alkanethiols and from surface-grafted PEG, which have been described previously. The data show that the new adsorbates form well packed and conformationally ordered films with contact angles of water ranging from 67° to 95°, depending on the precise structure of the acetal terminus. As a whole, the new SAMs offer a unique strategy for studying and designing adhesion-resistant biocompatible inferfaces. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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