| Autor: |
Lagrou, Lisa, Lalonde, Mandy, Moran, Kelley L., Sivak, Jacob G., Bantseev, Vladimir |
| Předmět: |
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| Zdroj: |
Cutaneous & Ocular Toxicology; 2005, Vol. 24 Issue 4, p247-256, 10p |
| Abstrakt: |
The optical properties of the cultured bovine lens were analyzed after exposure to various concentrations of Tween 20, a nonionic surfactant, to find a nonirritating concentration for commercial products. Bovine lenses were extracted and placed into a culture chamber for 24 hours at 37°C with 4–5% CO 2 . The lenses were placed into three treatment (1%, n = 10; 10%, n = 9; and 100%, n = 10 Tween 20) and one control group (n = 7) for 15 minutes. For 8 days following treatment, the lens optics were analyzed periodically for back vertex distance (focal length) and back vertex distance variability (sharpness of focus) using a laser-scanning device. For both the control and the 1% Tween 20 condition, no significant change was seen from the beginning of the experiment (p > 0.05). The 10% Tween 20 solution induced significant loss of sharp focus (0.62 ± 0.1 mm SEM) 4 hours after exposure, increasing to BVD = 1.69 ± 0.3 mm SEM by the end of experimentation (p [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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