| Autor: |
Pistone, T., Kony, S., Faye-Niang, M.A., Ndour, C.T., Gueye, P.M., Henzel, D., Delaporte, E., Badiane, S., N'Doye, I., Coulaud, J.P., Larouzé, B., Bouchaud, O. |
| Předmět: |
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| Zdroj: |
Transactions of the Royal Society of Tropical Medicine & Hygiene; Mar2002, Vol. 96 Issue 2, p167-172, 6p |
| Abstrakt: |
In industrialized countries the decision to start co-trimoxazole (CMX) prophylaxis of HIV-related opportunistic infections is based on the CD4+ cell count. The value of CMX prophylaxis has also been demonstrated in Africa, where CD4+ cell counts are rarely available. We therefore developed a simple score predictive of a threshold CD4+ cell count (400/mm3) below which CMX prophylaxis is indicated. In a retrospective cross-sectional study, we collected clinical and biological data on 211 HIV-infected patients recruited from January 1996 through January 1998 at Fann University Hospital in Dakar, Senegal. Several variables were identified as being predictive of a CD4+ cell count below 400/mm3 by stepwise logistic regression. Each variable was weighted according to its regression coefficient, as follows: male sex (+1), weight loss (+2), body mass index < 22 (+2), herpes zoster (+4), tuberculin induration < 5 mm (+3) and haemoglobin ≤ 10 g/dL (+1). A score of ≥ 4 (sum of weights) selected patients with CD4+ cell counts below 400/mm3 with a sensitivity of 98% and a negative predictive value of 83%. Such a score should be applicable in the African context and should facilitate the management of HIV-infected patients, especially the prescription of CMX prophylaxis. [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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