| Autor: |
Moon Woo Chun, Hyouk Woo Lee, Ae Yil Kim, Myong Jung Kim, Hea Ok Kim, Zhan-Guo Gao, Jacobson, Kenneth, Lak Shin Jeong |
| Předmět: |
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| Zdroj: |
Nucleosides, Nucleotides & Nucleic Acids; May2005, Vol. 24 Issue 5-7, p1119-1121, 3p, 1 Diagram |
| Abstrakt: |
Novel 3′-ureidoadenosine analogues were synthesized from 1,2:5,6-di- O -isopropylidene-d-glucose in order to lead to stronger hydrogen bonding at the A 3 adenosine receptor than the corresponding 3′-aminoadenosine derivatives. However, all synthesized 3′-ureidoadenosine analogues have lost their binding affinities to the all subtypes of adenosine receptors, indicating that bulky 3′-urea moiety led to conformational distortion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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