| Autor: |
Lim, L. S., James, V. H. T. |
| Předmět: |
|
| Zdroj: |
British Journal of Dermatology; Aug1974, Vol. 91 Issue 2, p135-143, 9p, 2 Charts, 3 Graphs |
| Abstrakt: |
In a group of patients with acne, the levels of plasma 17β-hydroxysteroids (a group of naturally occurring androgens), their diurnal variation and their binding to plasma proteins were investigated. No clear abnormality of plasma 17β-hydroxysteroid levels was present in the patients and neither was any consistent pattern of change seen through the 24 h. Basal (10.00 h) levels of total plasma 17β-hydroxysteroids were found to be elevated in four out of eighteen female patients with acne. These women were clinically indistinguishable from other female patients. The mean level of free 17β-hydroxysteroids was significantly higher in the female patients with acne than in controls (P<0.01). However, in male patients neither the mean basal level of plasma 17β-hydroxysteroids nor that of the free fraction was significantly different from controls. Indirect estimation of testosterone-binding globulin concentration also showed no differences either in the range, or in the mean level between patients and controls of both sexes. It is possible that the elevated level of free 17β-hydroxysteroids found in a few female patients contributed to the pathology of their disorder. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text