Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.

Autor: Carlton, Jez G., Bujny, Miriam V., Peter, Brian J., Oorschot, Viola M. J., Rutherford, Anna, Arkell, Rebecca S., Klumperman, Judith, McMahon, Harvey T., Cullen, Peter J.
Předmět:
Zdroj: Journal of Cell Science; 10/1/2005, Vol. 118 Issue 19, p4527-4539, 13p
Abstrakt: Focuses on the results of a study on the association of sorting nexin-2 with tubular elements of the early endosome and its importance to retromer-mediated endosome-to-thioguanine nucleotides transport. Identification of mammalian orthologues of all yeast retromer components; Effect of the endogenous sorting of nexins on the degradative sorting of receptors for epidermal growth factor or transferrin; Cause of the alteration in the kinetics of cation-independent mannose 6-phosphate receptor retrieval.
Databáze: Complementary Index