| Autor: |
Gizard, Florence, Robillard, Romain, Gervois, Philippe, Faucompré, Anne, Révillion, Françoise, Peyrat, Jean-Philippe, Hum, W. Dean, Staels, Bart |
| Předmět: |
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| Zdroj: |
FEBS Letters; Oct2005, Vol. 579 Issue 25, p5535-5541, 7p |
| Abstrakt: |
Abstract: The effects of progesterone derivatives on breast cancer development are still controversial, probably accounting for their biphasic, opposed effects on mammary cell-cycle regulation. Here, we demonstrate in vitro that the growth-inhibitory effects of progesterone on breast cancer T-47D cells require the transcriptional upregulation of the cyclin-dependent kinase inhibitor p27Kip1 (p27) gene. A statistical analysis of human tumor biopsies further indicates that p27 mRNA levels correlate to progesterone receptor (PR) levels. Moreover, p27 gene expression is inversely associated with tumor aggressiveness, and is a prognostic factor of favorable disease outcome. Thus, progesterone derivatives selectively activating the p27 gene promoter could be promising drugs against breast cancer progression. [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
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