| Autor: |
Hassan, J., Reen, D. J. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Jun1994, Vol. 39 Issue 6, p597-601, 5p, 2 Diagrams, 1 Chart, 1 Graph |
| Abstrakt: |
Expression of IL-2 mRNA by unstimulated and stimulated purified T cells and mononuclear cells from adult and cord blood was investigated in an attempt to better understand the underlying defective neonatal host immune defense system. Using RNA dot-blot analysis, IL-2 mRNA expression in anti-CD2-stimulated neonatal T cells revealed significantly reduced levels when compared to adult T cells (P < 0.01). Purified neonatal T cells also showed a significantly reduced proliferative response to anti-CD2 antibodies (P < 0.01). Addition of IL-1β enhanced the hyporesponsiveness of neonatal T cells at both the level of proliferation and IL-2 mRNA expression. Unseparated mononuclear cells from adult and cord blood revealed similar IL-2 mRNA levels and proliferation when activated by anti-CD2 stimulation. The reduced IL-2 mRNA expression observed in neonatal T cells may explain, in part, the difference in host defense between the newborn and adult during states of increased demand such as infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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