Cytokine Gene Expression During Infection of Mice Lacking CD4 and/or CD8 with Trypanosoma cruzi.

Autor:	Rottenberg, M. E., Sporrong, L., Persson, I., Wigzell, H., Örn, A.
Předmět:	CD4 antigen INFECTION NITRIC oxide MESSENGER RNA T cells LABORATORY mice
Zdroj:	Scandinavian Journal of Immunology; Feb1995, Vol. 41 Issue 2, p164-170, 7p, 2 Charts, 3 Graphs
Abstrakt:	The expression of lymphokine genes during infection of virulent (Tulahuén) or mild (CA-I) strains of T. cruzi was studied in mice lacking CD4 and/or CD8 molecules. The increased susceptibility of CD4- and CD4-CD8- mice to infection with CA-I or Tulahuén was parallelled by diminished IFN-γ mRNA levels. Nitric oxide release and inducible nitric oxide synthase mRNA accumulation by cells from Tulahuén infected CD4- mice was also diminished. CD8- (but not CD4-CD8- mice) showed an increased IL-4 and IL-10 mRNA accumulation upon infection with both strains of T. cruzi. A 'Th2-like' response (higher IL-4 and IL-10 mRNA to IFN-γ mRNA ratio), was also observed when cells from non-infected CD8- mice were stimulated with T cell mitogens. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text