A Correlation Between the Expression of the bcr-abl Chimeric Gene and Severity of the Clinical State of CML Patients with Time.

Autor:	Amikam, D., Henig, C., Carter, A., Sharon, R., Ben-Ishai, Z.
Předmět:	POLYMERASE chain reaction CHRONIC myeloid leukemia ONCOGENES POLYMERIZATION CHRONIC leukemia
Zdroj:	Scandinavian Journal of Immunology; Jun1995, Vol. 41 Issue 6, p529-533, 5p, 1 Diagram, 2 Graphs
Abstrakt:	Using the reverse polymerase chain reaction, four Ph′ positive CML patients were followed for 2 years; a correlation between the severity of the clinical state and the b3a2 expression was noted with time. Additionally, amplification of the c-myc proto-oncogene was observed, using Southern blot analysis, in one patient prior to his entry to the blast phase. No reorganization of the bcr-abl rearrangement site was found in the latter patient. The data suggest that a routine follow-up of CML patients using the Southern blot analysis and the reverse transcription-polymerase chain reaction might be of importance in evaluating the progression of the disease. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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