| Autor: |
Jouvenne, P., Fossiez, F., Banchereau, J., Miossec, P. |
| Předmět: |
|
| Zdroj: |
Scandinavian Journal of Immunology; Oct1997, Vol. 46 Issue 4, p413-418, 6p, 5 Charts, 1 Graph |
| Abstrakt: |
Neutralizing autoantibodies to interleukin (IL)-1α were detected in a subset of chronic polyarthritis patients characterized by an increased proportion of patients with primary Sjogren's syndrome or self-limiting inflammatory arthritis, diseases with a much better prognosis than rheumatoid arthritis (RA). The evolution of anti-IL-1α antibody levels was followed over 3 years. Incidence and levels were higher in patients with a benign form of polyarthritis. In these patients levels remained stable or increased over the follow-up period. In contrast, incidence and levels were lower and some RA patients became negative. Negative correlations were observed between the levels of anti-IL-1α antibodies and the clinical and biological indices of disease activity. The relative risk factor of developing RA was 12 in the absence of high anti-IL-1α antibody levels and 18.2 when associated with the presence of HLA-DR4. In conclusion, the presence of anti-IL-1α autoantibodies appears to be protective and their detection could represent a marker of good prognosis for destruction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text