Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition.

Autor:	Elkin, Robert G., Yan, Zhihong, Elkin, R G, Yan, Z, Zhong, Y, Donkin, S S, Buhman, K K, Story, J A, Turek, J J, Porter, R E Jr, Anderson, M, Homan, R, Newton, R S
Předmět:	HATCHABILITY of eggs ENZYME inhibitors PHYSIOLOGY PROTEIN analysis RNA metabolism METABOLISM EGGS ANIMAL experimentation ANTILIPEMIC agents CHOLESTEROL COMPARATIVE studies GENE expression IMMUNOBLOTTING LIPOPROTEINS LIVER RESEARCH methodology MEDICAL cooperation NUCLEOTIDE separation OXIDOREDUCTASES RESEARCH EVALUATION research PHARMACODYNAMICS POULTRY
Zdroj:	Journal of Nutrition; May99, Vol. 129 Issue 5, p1010-1019, 10p, 4 Charts, 6 Graphs
Abstrakt:	The inability to markedly attenuate cholesterol levels in chicken eggs has led to speculation that cholesterol is essential for yolk formation and that egg production would cease when yolk cholesterol deposition was inadequate for embryonic survival. However, this critical level hypothesis remains unproven. Here, we determine the relative responsiveness of laying hens to three select inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the rate-limiting enzyme of cholesterol biosynthesis. A control diet, either alone or supplemented with one of two dietary levels (0.03 or 0.06%) of atorvastatin, lovastatin, or simvastatin, was fed to White Leghorn hens for 5 wk. Liver cholesterol concentrations (mg/g tissue) were decreased (P 0.05), and 22% (P 0.05), and -3% (P > 0.05)], was much less affected. We concluded that cholesterol per se may not be an obligatory component for yolk formation in chickens and, as such, may be amenable to further pharmacological manipulation [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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