Prediction of the volume of large prostate cancers by multiple core biopsies.

Autor: Häggarth, Lars, Busch, Christer, Norberg, Mona, Häggman, Michael, Norlén, Bo-Johan, Egevad, Lars
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Zdroj: Scandinavian Journal of Urology & Nephrology; Nov2005, Vol. 39 Issue 5, p380-386, 7p
Abstrakt: Objective . To evaluate whether large-volume prostate cancers can be predicted by means of multiple needle biopsies. Material and methods . In 115 men, 8–14 (mean 10) biopsies were taken, including eight from standardized positions (apex, mid-medial, mid-lateral and base). Biopsies were reviewed, the length of the cancer measured and the percentage cancer length calculated. All men underwent radical prostatectomy. The prostatectomy specimens were totally embedded and the tumor volume was measured planimetrically. The predictive values of the number and percentage of cores positive for cancer, cancer length and percentage cancer length were calculated for tumor volumes of >4, >6 and >8 ml. Results . Using univariate logistic regression, cancer length and percentage cancer length predicted tumor volumes of >4 ( p 6 ( p 8 ml ( p 4 ml in 95% and 93% of cases, respectively. For tumor volumes of >6 or >8 ml, predictive values were lower. Tumor volumes of [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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