Recurrent respiratory tract infections during the first 3 years of life and atopy at school age.

Autor: Nystad, W., Skrondal, A., Njå, F., Hetlevik, Ø, Carlsen, K.-H., Magnus, P.
Předmět:
Zdroj: Allergy; Dec1998, Vol. 53 Issue 12, p1189-1194, 6p, 5 Charts
Abstrakt: Background The hypothesis that infections reduce the risk of atopy was investigated by estimating the association between recurrent respiratory tract infections during the first 3 years of life and atopy at school age. Methods According to surveys in three different areas of Norway, children were classified into three groups: asthma, wheeze without asthma (wheeze), and no asthma/no wheeze. The skin prick test (SPT) was conducted on a stratified random sample of children (n = 502). The outcome was at least one positive SPT, The exposure variable was retrospective parental report of respiratory tract infections during the first 3 years of life. Results Infections were negatively associated with atopy, crude odds ratio (cOR) = 0.3, 95% confidence interval (95% CI) 0.1-0,7, in the asthma group, A similar association was present in children with wheeze cOR = 0.4 (95% CI 0.1-1.2), The number of siblings was not associated with atopy in any group. Infections remained negatively associated with atopy in children with asthma, aOR = 0.3 (95% CI 0.1-0.7), in a logistic regression model adjusting for confounding factors, A similar pattern was present in the wheeze group. Conclusions Recurrent respiratory tract infections during the first 3 years of life are negatively associated with atopy at school age in children with asthma. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: