| Autor: |
Wirz, Stefan, Wartenberg, Hans-Christian, Wittmann, Maria, Nadstawek, Joachim |
| Předmět: |
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| Zdroj: |
Pain Clinic; 2005, Vol. 17 Issue 4, p367-376, 10p, 3 Charts, 2 Graphs |
| Abstrakt: |
Background and objective: The purpose of this trial was to compare the efficacy, safety and side effects of post-operative pain therapy using oral controlled release formulations of tramadol and oxycodone. Methods: In a prospective, randomized, double-blind investigation, we observed the post-operative course of 57 patients scheduled for orthopedic surgery. We assessed pain at rest and during exercise, vital signs and side effects using direct measuring and Numerical Rating Scales over a period of three post-operative days. We used chi-squared or Fisher's exact test for categorical variables and the Mann–Whitney U-test for numerical variables (p < 0.05). Results: Demographic medical data and pain levels did not differ between the two treatments. Parameters for vital signs remained stable. Nausea and emesis occurred significantly more frequently with tramadol (p = 0.011, p = 0.013). Despite insignificance, central effects such as sedation, insomnia, myoclonus or nightmares were more frequent with tramadol. During the post-operative period, dizziness and sedation were attenuated significantly in the tramadol group (p = 0.031, p = 0.015) as was dry mouth in the oxycodone group (p = 0.041). Conclusion: Our findings underline the efficacy of oral controlled release formulations of tramadol and oxycodone for post-operative pain therapy. Controlled release oxycodone was shown to cause less nausea and emesis than controlled release tramadol. Further investigation is needed in order to confirm these results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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