A phase I trial of high-dose palliative radiotherapy plus concurrent weekly Vinorelbine and Cisplatin in patients with locally advanced and metastatic NSCLC.
| Autor: | Michael, M., Wirth, A., Ball, D. L., MacManus, M., Rischin, D., Mileshkin, L., Solomon, B., McKendrick, J., Milner, A. D. |
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| Předmět: |
DRUG therapy
LUNG cancer CANCER patients METASTASIS CISPLATIN VINORELBINE SYMPTOMS THERAPEUTIC use of antineoplastic agents SURVIVAL RESEARCH CLINICAL trials RESEARCH methodology LUNG tumors EVALUATION research TREATMENT effectiveness TUMOR classification COMPARATIVE studies RADIATION doses COMBINED modality therapy VINBLASTINE |
| Zdroj: | British Journal of Cancer; 9/19/2005, Vol. 93 Issue 6, p652-661, 10p |
| Abstrakt: | The role of concurrent chemoradiotherapy (CRT) in patients with non-small-cell lung cancer (NSCLC) unsuitable for radical therapy but who require locoregional treatment has not been defined. The aims of this phase I trial were thus to develop a novel regimen of weekly chemotherapy concurrent with high-dose palliative RT (40 Gy/20 fractions) and assess its tolerability, objective and symptomatic response rates. Eligible patients had stage I-IIIB NSCLC unsuitable for radical RT or limited stage IV disease, ECOG PS |
| Databáze: | Complementary Index |
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