| Autor: |
Colville-Nash, Paul R., Gilroy, Derek W., Willis, Dean, Paul-Clark, Mark J., Moore, Adrian R., Willoughby, Derek A. |
| Předmět: |
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| Zdroj: |
Inflammopharmacology; 2005, Vol. 12 Issue 5/6, p473-476, 4p, 1 Graph |
| Abstrakt: |
Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2α concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2α produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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