Age-related differences in intracranial pressure and cerebral perfusion pressure in the first 6hours of monitoring after childrens head injury: association with outcome.

Autor: I. R. Chambers, L. Stobbart, P. A. Jones, F. J. Kirkham, M. Marsh, A. D. Mendelow, R. A. Minns, S. Struthers, R. C. Tasker
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Zdroj: Child's Nervous System; Mar2005, Vol. 21 Issue 3, p195-199, 5p
Abstrakt: Objectives Severe head injury in childhood is associated with considerable mortality and morbidity. In this study we determined age-related differences in the relationship between outcome and intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in the first 6h of monitoring in a large cohort of head-injured children. Methods Two hundred and thirty-five head-injured children (admitted to five UK hospitals over a 15-year period) in whom intracranial pressure monitoring was clinically indicated were studied. Results Patients were divided into three age groups (26, 710 and 1116years). The sensitivity of ICP and CPP were similar. Differences were found in the specificity of ICP and CPP for each group and these were more marked for CPP. For a specificity of 50% the pressures were 53, 63 and 66mmHg for the three age groups. Conclusions There are age-related differences in the specificity of intracranial pressure and cerebral perfusion pressure in relation to outcome. These differences may be important in the clinical management of head-injured children. Thus cerebral perfusion pressures of 53, 63 and 66mmHg should be the minimum to strive for in these three age groups respectively. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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